TY - JOUR T1 - Transcutaneous auricular vagus nerve stimulation (taVNS) for migraine: an fMRI study JF - Regional Anesthesia & Pain Medicine JO - Reg Anesth Pain Med SP - 145 LP - 150 DO - 10.1136/rapm-2020-102088 VL - 46 IS - 2 AU - Yue Zhang AU - Yiting Huang AU - Hui Li AU - Zhaoxian Yan AU - Ying Zhang AU - Xian Liu AU - Xiaoyan Hou AU - Weicui Chen AU - Yiheng Tu AU - Sierra Hodges AU - Helen Chen AU - Bo Liu AU - Jian Kong Y1 - 2021/02/01 UR - http://rapm.bmj.com/content/46/2/145.abstract N2 - Background Dysfunction of the thalamocortical connectivity network is thought to underlie the pathophysiology of the migraine. This current study aimed to explore the thalamocortical connectivity changes during 4 weeks of continuous transcutaneous vagus nerve stimulation (taVNS) treatment on migraine patients.Methods 70 migraine patients were recruited and randomized in an equal ratio to receive real taVNS or sham taVNS treatments for 4 weeks. Resting-state functional MRI was collected before and after treatment. The thalamus was parceled into functional regions of interest (ROIs) on the basis of six priori-defined cortical ROIs covering the entire cortex. Seed-based functional connectivity analysis between each thalamic subregion and the whole brain was further compared across groups after treatment.Results Of the 59 patients that finished the study, those in the taVNS group had significantly reduced number of migraine days, pain intensity and migraine attack times after 4 weeks of treatment compared with the sham taVNS. Functional connectivity analysis revealed that taVNS can increase the connectivity between the motor-related thalamus subregion and anterior cingulate cortex/medial prefrontal cortex, and decrease the connectivity between occipital cortex-related thalamus subregion and postcentral gyrus/precuneus.Conclusion Our findings suggest that taVNS can relieve the symptoms of headache as well as modulate the thalamocortical circuits in migraine patients. The results provide insights into the neural mechanism of taVNS and reveal potential therapeutic targets for migraine patients. ER -