Background/importance Anesthesiologists frequently use truncal catheters for postoperative pain control but with limited characterization of dosing and toxicity.
Objective We reviewed the published literature to characterize local anesthetic dosing and toxicity of paravertebral and transversus abdominis plane catheters in adults.
Evidence review We searched the literature for bupivacaine or ropivacaine infusions in the paravertebral or transversus abdominis space in humans dosed for 24 hours. We evaluated bolus dosing, infusion dosing and cumulative 24-hour dosing in adults. We also identified cases of local anesthetic systemic toxicity and toxic blood levels.
Findings Following screening, we extracted data from 121 and 108 papers for ropivacaine and bupivacaine respectively with a total of 6802 patients. For ropivacaine and bupivacaine, respectively, bolus dose was 1.4 mg/kg (95% CI 0.4 to 3.0, n=2978) and 1.0 mg/kg (95% CI 0.18 to 2.1, n=2724); infusion dose was 0.26 mg/kg/hour (95% CI 0.06 to 0.63, n=3579) and 0.2 mg/kg/hour (95% CI 0.06 to 0.5, n=3199); 24-hour dose was 7.75 mg/kg (95% CI 2.1 to 15.7, n=3579) and 6.0 mg/kg (95% CI 2.1 to 13.6, n=3223). Twenty-four hour doses exceeded the package insert recommended upper limit in 28% (range: 17%–40% based on maximum and minimum patient weights) of ropivacaine infusions and 51% (range: 45%–71%) of bupivacaine infusions. Toxicity occurred in 30 patients and was associated with high 24-hour dose, bilateral catheters, cardiac surgery, cytochrome P-450 inhibitors and hypoalbuminemia.
Conclusion Practitioners frequently administer ropivacaine and bupivacaine above the package insert limits, at doses associated with toxicity. Patient safety would benefit from more specific recommendations to limit excessive dose and risk of toxicity.
- Drug-Related Side Effects and Adverse Reactions
- Nerve Block
- Pain, Postoperative
- REGIONAL ANESTHESIA
- Postoperative Complications
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BB and LJ are joint first authors.
Twitter @BrittaniBungart, @mfettiplace
BB and LJ contributed equally.
Contributors MF conceived the project and designed the extraction. BB, LJ and MF all contributed to literature screening, data extraction, data preparation, manuscript drafting and manuscript editing.
Funding MF is supported by an NIH T32 training grant 5T32GM007592-42.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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