Background/importance There is heterogeneity among the outcomes used in regional anesthesia research.
Objective We aimed to produce a core outcome set for regional anesthesia research.
Methods We conducted a systematic review and Delphi study to develop this core outcome set. A systematic review of the literature from January 2015 to December 2019 was undertaken to generate a long list of potential outcomes to be included in the core outcome set. For each outcome found, the parameters such as the measurement scale, timing and definitions, were compiled. Regional anesthesia experts were then recruited to participate in a three-round electronic modified Delphi process with incremental thresholds to generate a core outcome set. Once the core outcomes were decided, a final Delphi survey and video conference vote was used to reach a consensus on the outcome parameters.
Results Two hundred and six papers were generated following the systematic review, producing a long list of 224 unique outcomes. Twenty-one international regional anesthesia experts participated in the study. Ten core outcomes were selected after three Delphi survey rounds with 13 outcome parameters reaching consensus after a final Delphi survey and video conference.
Conclusions We present the first core outcome set for regional anesthesia derived by international expert consensus. These are proposed not to limit the outcomes examined in future studies, but rather to serve as a minimum core set. If adopted, this may increase the relevance of outcomes being studied, reduce selective reporting bias and increase the availability and suitability of data for meta-analysis in this area.
- REGIONAL ANESTHESIA
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Collaborators Collaborators listed as main authors above.
Contributors Study concept, design and conduct: JH, TA, SW, MC. Systematic Review: JH, TA. Data collection: all authors. Manuscript preparation: JH, TA. Manuscript editing: JH, TA, SW, AJRM, KE-B, MC. Manuscript review and approval: all authors. Guarantor: JH.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests EA received grants from the Swiss Academy for Anaesthesia Research, Lausanne, Switzerland; B. Braun Medical AG, Sempach, Switzerland; and the Swiss National Science Foundation to support his clinical research. EA has also received an honorarium from B. Braun Medical AG Switzerland, Sintetica Ltd UK and MSD AG Switzerland. BF declares honoraria from B. Braun, Sintetica, Brain Therapeutics and Hospitality Medovate. ERM chairs the American Society of Anaesthesiologists Committee on Regional Anesthesia and Acute Pain Medicine. He is a former director of the American Society of Regional Anesthesia and Pain Medicine (ASRA). TA, AG, NH, DFJ, AJRM, AP, MPS, LT, SW, JW are members of the Board of Regional Anaesthesia UK (RA-UK). KE-B declares honoraria from GE Healthcare, Ambu, Fisher and Paykel, Edwards Lifesciences. AJRM declares honoraria and/or research funding from Intelligent Ultrasound. PM is a board member of European Diploma in Regional Anaesthesia (EDRA) and declares honoraria from B. Braun Medical and Medovate. AP declares honoraria from GE Healthcare, Butterfly Net, Sintetica UK and Pacira. KR was the President of the British Association of Day Surgery.
Provenance and peer review Not commissioned; externally peer reviewed.
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