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Brief technical report
Use of three-dimensional printing of a lumbar skeletal model for intrathecal administration of nusinersen: a brief technical report
  1. Hiroaki Abe1,
  2. Reo Inoue2,
  3. Rikuhei Tsuchida2,
  4. Kenji Azuma1,
  5. Kenji Ino3,
  6. Mitsuru Konishi1,
  7. Jun Hozumi4 and
  8. Masahiko Sumitani1
  1. 1Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Bunkyo-ku, Japan
  2. 2Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
  3. 3Department of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
  4. 4Department of Medical Community Network and Discharge Planning, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
  1. Correspondence to Dr Masahiko Sumitani, Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Bunkyo-ku 113-0033, Japan; SUMITANIM-ANE{at}h.u-tokyo.ac.jp

Abstract

Spinal muscular atrophy (SMA) is an autosomal recessive hereditary neurodegenerative disease causing progressive muscle atrophy, weakness and kyphoscoliosis. Nusinersen is a therapeutic agent for SMA that should be administered intrathecally. However, due to severe kyphoscoliosis, lumbar puncture can be challenging. Here, we present our experience of intrathecal administration of nusinersen in an SMA patient with severe kyphoscoliosis using a life-size three-dimensional printing (3D) skeletal model created with 3D printer. With this strategy, we were able to rapidly and safely perform the lumbar puncture.

  • diagnostic techniques and procedures
  • injections, spinal
  • multimodal imaging

https://doi.org/10.1136/rapm-2020-101607

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    Footnotes

    • Contributors HA conceived the original idea, performed practical procedure and prepare manuscript. RI performed practical procedure. RT performed practical procedure. KA revised manuscript. KI supervised handling of 3D-CT data. MK handled 3D-CT data and created the skeletal model. JH handled 3D-CT data and created the skeletal model. MS acquired funding, revised manuscript and approved final manuscript.

    • Funding This study was funded by JSPS KAKENHI grant number 19H03749.

    • Competing interests None declared.

    • Patient consent for publication Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.