Plasma concentrations of lidocaine were measured over a period of 3 hours following endotracheal intubation of patients with tubes which were lubricated with lidocaine 5% (Xylocaine®) ointment (18 patients) or lidocaine 2% (Xylocaine® HCI) Jelly (16 patients). The average amount of ointment or jelly used on the tubes was 1.25 g (0.49-2.45 g). Peak blood levels were obtained within 5 to 15 minutes after intubation. The mean peak level was about 0.5 μg/ml for the ointment and below the accurately measurable level for the jelly. The highest peak plasma concentration of 0.9 μg/ml was obtained with the ointment in one patient within the first 5 minutes after intubation. Following use of the jelly, at no time did plasma concentration exceed 0.2 mcg/ml. With both preparations the levels of lidocaine were far below those producing systemic effects.
- Plasma concentrations
- Endotracheal intubation
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.