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Comparative Analgesic Properties of Bupivacaine, Etidocaine, and Lidocaine in Mice
  1. Paul A. Moore, DMD, PhD,
  2. Robert G. Burney, MD and
  3. Harry A. Dunlevy, BS
  1. From the Harvard School of Dental Medicine, Boston, and the University of Massachusetts Medical Center, Worcester, Massachusetts


The analgesic properties of bupivacaine, etidocaine, and lidocaine were compared following intraperitoneal injection in mice. Two evaluations of analgesia were employed: the hot plate test and the stretch test. Doses of 75% of their corresponding CD50s produce analgesia greater than control and less than morphine sulfate 5 mg/kg. When differences in the pharmacokinetic properties of the agents are evaluated, the relative analgesic properties of the three local anesthetics appear nearly identical.

  • Anesthetics
  • bupivacaine
  • etidocaine
  • lidocaine
  • Analgesia
  • Pharmacokinetics
  • Tests
  • hot plate
  • stretch
  • mice

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  • Support for this project was provided in part through NIDR R23‐DEO5507.

    Address reprint requests to Dr. Moore: Director, Pain Control Unit, Harvard School of Dental Medicine, 188 Longwood Avenue, Room 1‐107, Boston, MA 02115.

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