The effects of 5% topical etidocaine aerosol applied to the larynx and tracheobronchial tree and its ability to attenuate the cardiovascular responses occurring after laryngoscopy and endotracheal anesthesia was studied in a double blind study in 60 patients who received either 5% etidocaine or placebo. The results of this study showed smaller rise in diastolic pressure in the etidocaine group (p < 0.025) as compared to placebo. There also appeared to be a greater rise in heart rate in the etidocaine group (p < 0.025) in response to spraying.
- cardiac response
- topical anesthesia
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This study was supported by Astra Pharmaceutical Products, Inc.
Address reprint requests to Dr. Johnston: Department of Anesthesia (531), University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267.