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Effect of Age on Local Anesthetic Central Nervous System Toxicity in Mice
  1. Philip L. Liu, MD,
  2. Brian M. Covino, MS and
  3. Hal S. Feldman, BSc
  1. From the Department of Anaesthesia, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts


In order to determine the effect of age on local anesthetic central nervous system toxicity, the median convulsant dose (CD50) and median lethal dose (LD50) of etidocaine, bupivacaine, lidocaine, and chioroprocaine were determined in immature, adult and elderly mice. The results indicate that there is little difference in the potential systemic toxicity of lidocaine and chloroprocaine between different age groups. However, the acute systemic toxicity of the highly lipid soluble agents, etidocaine and bupivacaine, was significantly less in elderly mice compared to the immature mice.

  • Convulsive dose
  • Lethal dose
  • Bupivacaine
  • Etidocaine
  • Lidocaine
  • Chloroprocaine
  • Aging

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  • Address reprint requests to Dr. Liu: Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.

    Supported in part by a grant from AB Astra, Sweden.

    Presented in part at the Section on Anesthesiology, American Academy of Pediatrics, Spring Session, Honolulu, Hawaii, March, 1982.