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Effects of Baricity and Concentration of Tetracaine Solutions on Experimental Spinal Anesthesia in Sheep
  1. Maxim I. LeBeaux, D.V.M.*,
  2. Hal S. Feldman, A.A., B.Sc. and
  3. Benjamin G. Covino, Ph.D., M.D.
  1. From the Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, and Astra Research Laboratories, Worcester, Massachusetts
  1. Address reprint requests to: Dr. Covino, Department of Anesthesia, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.


A series of experiments were conducted to evaluate the effects of hypobaric, isobaric, and hyperbaric solutions of 0.5% tetracaine administered intrathecally to sheep. In a second series of similar experiments, the effect of alterations in local anesthetic concentration was studied following the subarachnoid injection of 0.25%, 0.5% and 1.0% hyperbaric tetracaine. The results indicate no statistically significant difference in onset, duration or spread of anesthesia between the test solutions of different baricity. A significantly longer duration of anesthesia was observed with the 0.5 and 1.0% concentrations of tetracaine as compared to the 0.25% concentration. However, no difference in onset and spread of anesthesia was observed with the various concentrations of tetracaine.

  • Anesthesia
  • spinal
  • Tetracaine
  • baricity

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