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Benzodiazepine Treatment of Seizures from Supraconvulsant Doses of Local Anesthetics
  1. Rudolph H. de Jong, M.D. and
  2. Richard A. DeRosa, Ph.D.
  1. From the Anesthesia Research Laboratories, Tufts University School of Medicine, Boston, Massachusetts
  1. Address reprint requests to Dr. de Jong: Anesthesia Research Laboratories, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111.

Abstract

The anticonvulsant effects of lorazepam and diazepam were tested in 40 ventilated paralyzed cats given double or triple the convulsant dose of an amide local anesthetic. Lidocaine-induced convulsions were more readily suppressed by lorazepam than those induced by bupivacaine. With bupivacaine-induced convulsions, diazepam was a more effective anticonvulsant than lorazepam. Seizures from triple the convulsant dose of etidocaine were approximately as readily arrested by diazepam as were those from double the convulsant dose of bupivacaine. We conclude that etidocaine- and bupivacaine-induced convulsions are more resistant to benzodiazepine treatment than convulsions induced by lidocaine.

  • Anesthetics, local
  • Bupivacaine
  • Etidocaine
  • Lidocaine
  • Anticonvulsants
  • Diazepam
  • Lorazepam
  • Complications, convulsions, hemolysis

https://doi.org/10.1136/rapm-00002370-198104000-00002

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    Footnotes

    • Read in part at the meeting of the American Society of Regional Anesthesia, Atlanta, Georgia, March 12 to 15, 1981.

    • This work was supported by a grant from Breon Laboratories.