Article Text

Download PDFPDF
Degenerative Lesions in Rat Sciatic Nerves After Local Injections of Methylprednisolone in Sterile Aqueous Suspension
  1. Kathleen M. Wood, MD,
  2. Jaime Arguelles, MD and
  3. Michael D. Norenberg, MD
  1. Dr. Wood is associate professor and Dr. Arguelles is senior clinical fellow, department of anesthesiology, University of Colorado Medical Center. Dr. Norenberg is associate professor, department of anesthesiology, Veterans Administration Hospital, Denver.


Rat sciatic nerves were exposed to injections of methylprednisolone acetate suspension (MPAS), the suspension vehicle without methylprednisolone, a local anesthetic (chloroprocaine 1%), and repeated needle punctures. The nerves were taken for histological study and compared with untreated controls. Nerves treated with the methylprednisolone suspension and its sterile vehicle showed similar incidence and severity of patchy degenerative changes, including demyelination, axonal disorganization, and endoneurial collagen formation. These findings suggest that repeated injections of MPAS near a peripheral nerve may cause nerve damage.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • This project was supported in part by BRSG Grant RR-0537, awarded by the Biomedical Research Grant Program, Division of Research Resources, National Institutes of Health, and the Research Service of the Veterans Administration Hospital; further support was donated by the Upjohn Company, Kalamazoo, Michigan.