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Abstract
Please confirm that an ethics committee approval has been applied for or granted: Not relevant
Background and Aims Hypoxemia (low blood oxygen) is the most common problem during gastrointestinal endoscopy with sedation. The best way to deliver oxygen for prevention is unclear. This study aimed to compare different oxygen delivery methods to prevent hypoxemia.
Methods Researchers searched major medical databases in June 2023. They included studies comparing oxygen therapies (vs. placebo or other methods) in adults undergoing endoscopy with sedation. Two reviewers independently analyzed the data following standard guidelines.
Results The study included 27 studies with over 7,500 patients. Compared to a nasal cannula (standard method), non-invasive ventilation (NIPPV) was most effective in preventing hypoxemia, followed by the Wei nasal jet tube (WNJT). Efficacy ranked: NIPPV > WNJT > other methods > nasal cannula.
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Conclusions All advanced oxygen therapies were better than the standard nasal cannula for preventing hypoxemia during endoscopy with sedation. NIPPV and WNJT seem most effective. Clinicians should choose the best method based on patient risk, procedure type, and potential side effects. This provides valuable evidence for clinical practice.