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Background and Aims Constant military conflicts in the world and a full-scale war in Ukraine make the study and improvement of pain management relevant. Pain is an unpleasant or painful sensation, an experience of emotional or physical suffering. In general, injuries can be divided into background, breakthrough and procedural pain. There are many pain rating scales that must be used to categorize casualties into levels of pain relief. The modern approach to multimodal analgesia of injuries and wounds is generally accepted in the world. The earliest possible start of high-quality and comprehensive pain relief is the key to the success of analgesia and the prevention of chronic pain. An important place for pain relief at the stages of evacuation and in hospitals is occupied by ketamine, NSAIDs, paracetamol, opiates and regional techniques. Currently, the world is experiencing a flourishing of regional anesthesia, which is especially associated with the nature of combat wounds. A significant part of combat injuries are characterized by damage to the extremities, and this is associated with very intense pain and chronic pain. The most important role is played by the use of ultrasound for precise navigation when performing conduction and planar blocks. In addition, one must remember the mental component of pain and the need to add sedatives when needed. However, further research is needed to improve wound pain management. Future research may be needed on the effects of new analgesics, new regional anesthesia techniques, music, virtual reality, hypnosis, acupuncture, and other modalities on pain relief.