Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page)

Background and Aims Fibromyalgia, a complex chronic pain syndrome, presents significant therapeutic challenges due to its multifactorial nature and varied symptomatology. A personalized, multimodal approach is essential for effective management, considering its diverse manifestations and individual patient factors.

Methods Patient S.F., a 28-year-old female from Algiers, diagnosed with fibromyalgia according to the 2010 ACR criteria. She experienced chronic diffuse pain for 2 years, with comorbidities including psoriasis, gastritis, and functional colopathy. Despite normal paraclinical investigations, she reported moderate neuropathic pain (DN4 score 5/10) and severe pain intensity (VAS 8/10, pain score 16/18). Treatment included pregabalin and amitriptyline, alongside non-pharmacological interventions like relaxation sessions and physiotherapy. Psychological support was provided, and mesotherapy was attempted but ineffective. At the 4-month follow-up, pain intensity reduced significantly (VAS 3/10, DN4 1/10), with improved sleep quality and mood. The patient planned marriage and showed satisfactory therapeutic compliance, reducing productivity losses at work. She had a family history of rheumatoid arthritis and moderate anxiety and depression scores (HAD). Recommendations included gentle physical exercises and educational sessions on fibromyalgia.

Results Significant improvements in pain intensity, sleep quality, and mood were noted during the 4-month follow-up period. The patient reported high treatment satisfaction, enhanced coping skills, and reduced functional impairment, underscoring the effectiveness of the integrated approach.

Conclusions This case highlights the importance of addressing fibromyalgia through a holistic lens, integrating evidence-based interventions from various disciplines to meet the complex needs of patients. Additionally, it emphasizes the role of patient education and empowerment in fostering self-management and treatment adherence.