Background and Aims Fibromyalgia is a disorder that affects many people around the world, with symptoms that include diffuse chronic musculoskeletal pain, fatigue, unrefreshing sleep, cognitive dysfunction, headaches, and morning stiffness. The pain associated with fibromyalgia can be difficult to manage. The aim of this revision is to analyze the potential of new therapeutic agents for the pain management of patients with fibromyalgia.

Methods A systematic review was conducted to identify articles published after 2017, which evaluated the efficacy of novel therapeutic agents in pain management for fibromyalgia patients.

Results Pharmacological treatment options for fibromyalgia include cannabinoids and anti-nerve growth factor agents, which have shown effectiveness in reducing pain and improving sleep. Non-pharmacological interventions, such as non-invasive brain stimulation and mind-body therapies, have also been shown to aid in fibromyalgia pain management. Transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, has been shown to reduce pain in patients with fibromyalgia. Mind-body therapies, on the other hand, have been shown to reduce stress and help patients cope with fibromyalgia.

Conclusions Combining pharmacological and non-pharmacological interventions may provide the most effective treatment approach. Treatment plans need to be individualized, as each person can develop fibromyalgia for different reasons. While some people may respond well to a combination of medications and physical therapy, others may benefit more from physical therapy alone. There is still a need for more effective and targeted treatments for fibromyalgia-associated pain. Further research is needed to fully understand the mechanism of action, safety, and efficacy of these interventions in fibromyalgia patients.