Background and Aims Diabetic peripheral neuropathy (DPN) is a commonly occurring and incapacitating complication of diabetes, frequently leading to considerable discomfort and reduced patient well-being. The existing therapeutic modalities for DPN are constrained in their efficacy, prompting the exploration of spinal cord stimulation (SCS) as a viable alternative for pain mitigation. This investigation aims to provide a current synopsis of the latest literature on the effectiveness and safety of SCS in managing DPN.

Methods The study employed a literature search approach, utilizing the most current and pertinent sources. The analysis incorporated studies published after 2017, comprising clinical trials, observational studies, and position statements. The study centered on the effectiveness, safety, and comparative analysis of various spinal cord stimulation (SCS) systems employed in treating diabetic peripheral neuropathy (DPN).

Results Recent findings indicate that Spinal Cord Stimulation (SCS) is a secure therapeutic alternative for individuals diagnosed with Diabetic Peripheral Neuropathy (DPN). Several studies have reported noteworthy reductions in pain and enhancements in quality of life. The scholarly literature underscores the significance of selecting the suitable SCS system following the specific requirements of each patient, given that different systems present various advantages and disadvantages.

Conclusions In conclusion, SCS exhibits potential as a viable treatment alternative for DPN, providing pain alleviation and enhanced quality of life for individuals who have experienced limited efficacy from conventional therapies. Prospective studies are needed to optimize spinal cord stimulation (SCS) parameters, determine predictors of treatment response, and assess long-term outcomes to enhance the effectiveness of SCS in managing DPN.