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Background and Aims Antimicrobial resistance (AMR) has become a global issue. Not only decreasing the treatment options but serious threat to low-income countries associated with both misuse and overuse of antibiotics. This study has determined the antibiogram profile of patients admitted in SURGICAL icu (SICU) at Doctors Hospital and Medical Centre, Lahore.
Methods This study was retrospective cross-sectional in nature.Total 502 patients were admitted in ICU during our study period.Blood, tracheal and urine culture reports of 364 patients were recorded for the purpose of study.All cultures were processed in accordance with standard microbiological protocols defined by CLSI. CLED used for urine cultures, while Mac-Conkey, Choclate and Blood Agar were being used for tracheal and sputum cultures. Blood cultures were processed on BACT/ALERT automated blood culture system.Statistical analysis were performed using the SPSS 64-bit version.
Results Among 364 patients analyzed in the study, the cultures obtained from different sites were Blood (54%), Urine (33%) and tracheal (13%). Among blood cultures, no organism was isolated.Among tracheal cultures, most common organisms isolated were Klebsiella (5), followed by Acinetobacter
(4) and Pseudomonas (3).Among urine cultures, most common organism isolated was E. coli (4), then Klebsiella (3) and Pseudomonas (2).Vancomycin and Linezolid showed zero percent resistance to Staphylococcus sp. Collistin showed zero percent resistance for Acinetobacter and Klebsiella. Moxifloxacin was resistant for E. coli.
Conclusions The gram-negative bacteria were the major cause of infection in the ICU. Gram negative organisms(88.46%) were detected more than gram positive organisms(11.53%). We need to prescribe broad-spectrum antibiotics more wisely to reduce pressure on sensitive strains.
Attachment antibiogram dhmc.docx
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