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EP211 Importance of purine metabolites in preeclampsia and acute brain stroke
  1. Evgeny Oreshnikov1,
  2. Svetlana Oreshnikova1,
  3. Denisova Tamara2,
  4. Elvira Vasiljeva2 and
  5. Alexander Oreshnikov3
  1. 1Anesthesiology and Intensive Care, Chuvash State University, Cheboksary, Russia
  2. 2Obstetrics and gynecology, Chuvash State University, Cheboksary, Russia
  3. 3Internal Medicine, Chuvash State University, Cheboksary, Russia


Background and Aims Along with the edema, proteinuria, hypertension, many clinicians as indicator of preeclampsia using high content of uric acid in blood serum – hyperuricemia. It was also found that the hypoxanthine, xanthine and uric acid (UA) are present in the brain, UA is end product of purine degradation in the brain, and then in UA and can be a source of free radicals, endogenous increased production, with the’side’ synthesis of xanthine oxidase oxygen free radicals, reflects the severity of ischemic andreperfusion injury. Our attention was attracted by a comparative assessment of the features of purine metabolism in women with preeclampsia and acute brain stroke.

Methods The study involved 33 women with preeclampsia and 350 women in acute period of cerebral stroke, in which, in addition to conventional laboratory parameters were determined in blood and cerebrospinal fluid – guanine, hypoxanthine, adenine, xanthine and uric acid by direct spectrophotometry.

Results It was established that between preeclampsia and cerebral stroke there are clinical and pathobiochemical parallels, including according to the characteristics of purine metabolism. Hyperuricemia the most famous and at the same time the most pronounced adverse metabolic factor (marker or predictor) for preeclampsia, and for cerebral stroke. High value level of oxypurines (hypoxanthine, xanthine and uric acid) in the cerebrospinal fluid is good sign for a stroke, and low value level of oxypurines is good sign for preeclampsia.

Conclusions Cerebrospinal liquor can be seen not only medium of administration of drugs for spinal anesthesia, but also and a source of valuable diagnostic (and predictive) information.

  • preeclampsia
  • purine metabolites
  • stroke

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