Background and Aims It is known that more than 40% of pregnant women have a deficiency of vitamin D. Many clinicians used hyperuricemia as indicator for preeclampsia. We study the relationship of pain in childbirth, characteristics of epidural analgesia in women with preeclampsia, blood serum level of uric acid and free vitamin D.
Methods The study group included patients with severe and moderate preeclampsia, alone have given birth vaginally with epidural analgesia. The control group – patients with physiological pregnancy, independently gave birth vaginally with epidural analgesia. Free vitamin D level was performed by enzyme immunoassay kits. The concentration of uric acid was determined spectrophotometrically. Primary study end points defining a base for the conclusions were as follows: level of free vitamin D, uric acid, the average period for delivery systolic and diastolic blood pressure in mmHg, dose of local anesthetic.
Results In patients with severe preeclampsia revealed: a pronounced deficiency of vitamin D, a tough hyperuricemia, had higher numbers mean arterial pressure du ring labor epidural analgesia in the background: on average during all periods of childbirth 140/90-150/100 mm Hg. In patients with moderate preeclampsia was diagnosed moderate vitamin D deficiency, mild hyperuricemia, blood pressure during childbirth averaged 130/90-125/85 mm Hg. In the control group the level of free vitamin D and the concentration of uric acid were in the normal range, blood pressure during labor averaged 105/60-120/70 mm Hg.
Conclusions In women with preeclampsia, low levels of free vitamin D and hyperuricemia are associated with higher demand for local anesthetics during epidural analgesia.
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