Background and Aims CRBD is a troublesome sequela to an indwelling urinary catheterization that is commonly related to a number of postoperative complications, patient distress and increased length of hospital stay. The aim of this study is to evaluate the effect of 75 mg and 150 mg oral pregabalin pretreatment for the prevention of CRBD.

Ethical approval has been granted by the ethics committee.

Methods Patients undergoing transurethral resection of bladder tumor were blindly randomly allocated into 3 groups. Group I patients received placebo, Group II patients received 75mg of pregabalin and Group III patients received 150 mg of pregabalin 1 hour prior to the operation.Catheter-related bladder discomfort was evaluated on a 4-point scale in 5 different time intervals.

Results 78 patients were enrolled in the study.There was no difference between the demographic profile and operative variables such as surgical and anaesthesia time between the groups(p >0.05).The incidence of CRBD was 82% in group I, 62.5% in group II, and 34.6% in group III.Statistically significant decrease in CRBD was observed in all patients administered with pregabalin regardless of drug dosage compared to placebo (p<0.05). Group III patients presented with statistically significant less CRBD compared to Group II patients 2 and 6 hours postoperatively.

Conclusions Pregabalin 150mg is more effective in decreasing the incidence of postoperative CRBD compared to pregabalin 75 mg.