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Visceral versus somatic pain: an educational review of anatomy and clinical implications
  1. Andre P Boezaart1,2,
  2. Cameron R Smith1,
  3. Svetlana Chembrovich1,
  4. Yury Zasimovich1,
  5. Anna Server3,
  6. Gwen Morgan4,
  7. Andre Theron4,
  8. Karin Booysen5 and
  9. Miguel A Reina1,6
  1. 1 Anesthesiology, University of Florida, Gainesville, Florida, USA
  2. 2 Lumina Pain Medicine Collaborative, Surrey, UK
  3. 3 Anesthesiology, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain
  4. 4 Syncerus Care, George, Western Cape, South Africa
  5. 5 Private Anesthesiology Practice, Pretoria, Gauteng, South Africa
  6. 6 Department of Anesthesiology, CEU San Pablo University Faculty of Medicine, Alcorcon, Madrid, Spain
  1. Correspondence to Dr Andre P Boezaart, Anesthesiology, University of Florida, Gainesville, FL 32610, USA; ABoezaart{at}


Somatic and visceral nociceptive signals travel via different pathways to reach the spinal cord. Additionally, signals regulating visceral blood flow and gastrointestinal tract (GIT) motility travel via efferent sympathetic nerves. To offer optimal pain relief and increase GIT motility and blood flow, we should interfere with all these pathways. These include the afferent nerves that travel with the sympathetic trunks, the somatic fibers that innervate the abdominal wall and part of the parietal peritoneum, and the sympathetic efferent fibers. All somatic and visceral afferent neural and sympathetic efferent pathways are effectively blocked by appropriately placed segmental thoracic epidural blocks (TEBs), whereas well-placed truncal fascial plane blocks evidently do not consistently block the afferent visceral neural pathways nor the sympathetic efferent nerves. It is generally accepted that it would be beneficial to counter the effects of the stress response on the GIT, therefore most enhanced recovery after surgery protocols involve TEB. The TEB failure rate, however, can be high, enticing practitioners to resort to truncal fascial plane blocks. In this educational article, we discuss the differences between visceral and somatic pain, their management and the clinical implications of these differences.

  • anesthesia
  • local
  • autonomic nerve block
  • nerve block
  • pain perception
  • regional anesthesia

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  • Contributors All authors contributed to the researching, drafting, and final writing and approval of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

  • Author note A paper by Wahal et al 92 published after acceptance of this manuscript demonstrated that ischemic and visceral pain have a shared anatomic conduction pathway – namely Aδ and C fibers associated with the sympathetic nerves. With this in mind, ischemic pain should be viewed as a form of visceral pain.