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ESRA19-0640 The effect of intravenous dexamethasone on pain relief, blood glucose and lactate levels after hip atheroplasty
  1. I Golubovska1,
  2. A Miscuks2,
  3. S Zadoroznijs2,
  4. L Repsa3 and
  5. N Buraka2
  1. 1Hospital of Traumatology and Orthopaedics, Anaesthesia and Intensive Care Unit, Riga, Latvia
  2. 2University of Latvia, Faculty of Medicine, Riga, Latvia
  3. 3Hospital of Traumatology and Orthopaedics, Joint Replacement Department, Riga, Latvia


Background and aims Dexamethasone provides anti-inflammatory and analgesic effect, but induces hyperglycemia and may increase serum lactate. the aim was to determine the effect of dexamethasoneon analgesia, blood glucose and lactate after hip arthroplasty.

Methods This prospective randomized study includes 32 patients undergoing hip replacement. It was provided SA and patients received multimodal analgesia. the experimental group received Dexamethasone 8 mg i/v before surgery and 4 mg i/v in a 6 and 12 hours after the first dose. the control group did not receive any glucocorticoids. Blood glucose and lactate were measured before surgery,at 18:00 and 6:00 on the POD1. Patients filled in a pain questionnaire. Data were processed using SPSS programme.

Results The intensity of pain did not differ before surgery. At rest, it was 1.2 VAS in the experimental group and 3.0 in the control group (p<0.05) at 18:00, and 0.8 and 2.69, respectively, at 6:00 (p<0.005), but on movement, it was 1.4 and 3.6 (p<0.05) at 18:00 and 1.5 and 3.8 at 6:00 (p<0.005), respectively. Glucose of the experimental and control groups was 5.5 and 5.4 mmol/l, respectively, before surgery; 8.0 and 6.6 mmol/l at 18:00; and 7.2 and 5.6 mmol/l at 6:00. Lactate of the experimental and control groups was 0.9 and 1.5 mmol/l, respectively, before surgery; 1.6 and 1.3 mmol/l (p 0.254) at 18:00; and 1.7 and 1.1 mmol/l (p <0.05) at 6.00.

Conclusions Dexamethasone provides excellent analgesic effect and serum glucose and lactate does not reach recovery affecting level during perioperative period after hip replacement.

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