Background and aims Pulsed radiofrequency (PRF) is being increasingly used as a treatment option for chronic neuropathic pain syndromes.

The authors report regarding, to their knowledge, the novel use of PRF of the femoral nerve in the pain management of a 66-year-old female, diagnosed with CRPS in accordance with the Budapest consensus criteria following unilateral total knee replacement surgery.

Methods Three consecutive sessions, with 2-month intervals, of ultrasound guided femoral nerve PRF therapy were administered to the affected CRPS limb applying 6 min, 42 °C, 45V, 5Hz, 5 Ms.

Pre-treatment Brief Pain Inventory (BPI) and McGill-Pain-Questionnaire Short-Form (MPQ) were recorded and subsequently repeated at the completion of the proposed treatment, supplemented with the Patient’s Global Impression of Change Scale.

Results The subject reported objective improvement in symptoms and associated function following the sessions of PRF when comparison of the baseline BPS/MPQ-SF were analysed. Clinical apparent improvements in swelling, vasomotor instability, sudomotor abnormality, and motor function of the affected lower limb were noted with associated reduction in required oral analgesic medications.

Conclusions Pulsed radiofrequency of femoral nerve has the potential to be a useful treatment modality in the pain management of CRPS affecting this anatomical region and further exploration of its utility is required.