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Intermittent bolus versus continuous infusion popliteal sciatic nerve block following major foot and ankle surgery: a prospective randomized comparison
  1. Anthony James Short1,
  2. Meela Ghosh2,
  3. Rongyu Jin3,
  4. Vincent W S Chan3 and
  5. Ki Jinn Chin3
  1. 1 Department of Anaesthetics, Wrightington, Wigan and Leigh NHS Foundation Trust, Wigan, UK
  2. 2 Department of Anaesthetics, Freeman Hospital, Newcastle upon Tyne, Newcastle upon Tyne, UK
  3. 3 Department of Anesthesia, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to Dr Ki Jinn Chin, Department of Anesthesia, University of Toronto, Toronto, Canada; gasgenie{at}gmail.com

Abstract

Background and objectives Foot and ankle surgery is associated with severe pain that can be reduced with continuous popliteal sciatic nerve block. We tested the hypothesis that programmed intermittent bolus (PIB) delivery of local anesthetic provides superior analgesia to a continuous infusion (CI) regimen.

Methods 60 patients undergoing major foot and ankle surgery were randomized to receive PIB (10 mL of ropivacaine 0.2% every 2 hours) or CI (5 mL/hour) continuous popliteal sciatic nerve block with patient-controlled regional analgesia (5 mL every 30 min as needed) provided for all. Primary outcome was the average of static and dynamic numerical rating scale (NRS) pain scores through 48 hours. Secondary outcomes included rest and movement NRS pain scores at different timepoints, opioid consumption, local anesthetic consumption, intensity of sensory and motor block, patient satisfaction and the incidence of opioid-related side effects.

Results There was no significant difference in the primary outcome of average NRS pain score through 48 hours, opioid consumption or the volume of local anesthetic administered. Patients in group PIB had significantly decreased strength of toe dorsiflexion at 6 hours (p=0.007) and 12 hours (p=0.001) and toe plantarflexion at 12 hours (p=0.004). Patient satisfaction and the incidence of side effects was similar between groups.

Conclusions Both CI and PIB regimens provided excellent analgesia, low opioid consumption and high patient satisfaction. While there was no difference in analgesic outcomes, PIB dosing resulted in a more profound motor block.

Trial registration number NCT02707874.

  • Continuous Peripheral Techniques
  • Lower Extremity
  • Ultrasound in Pain Medicine
  • Postoperative Pain
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Footnotes

  • Twitter @tony_short

  • Presented at Prior presentation: interim data from this work were presented at the 2016 Regional Anesthesiology and Acute Pain Medicine Meeting of the American Society of Regional Anesthesia and Pain Medicine in New Orleans, 31 March–2 April 2016.

  • Contributors AJS: acquisition of data, analysis and interpretation of data and manuscript preparation and revision. MG: conception and design of study, planning, conduct and acquisition of data. RJ: conduct of study, acquisition of data and manuscript preparation. VWSC: conception and design of study, planning, interpretation of data and manuscript preparation and revision. KJC: conception and design of study, planning, conduct, acquisition of data, analysis and interpretation of data and manuscript preparation and revision.

  • Funding This study was supported by a financial grant and equipment supplies from Smiths Medical. Dr Ki Jinn Chin is supported by a Merit Award from the Department of Anesthesia, University of Toronto.

  • Competing interests VWSC has received honorarium from Aspen Pharma, BBraun, Smiths Medical and SonoSite. The other authors declare no conflicts of interest.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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