Article Text

Download PDFPDF
Antioxidation Role of Different Lateral Stellate Ganglion Block in Isoproterenol-Induced Acute Myocardial Ischemia in Rats
  1. Na Wei, MD*,
  2. Meng Chi, MD*,
  3. Lin Deng, MD* and
  4. Guonian Wang, MD*,
  1. *Department of Anesthesiology, Cancer Hospital of Harbin Medical University, Harbin; and †Pain Research Institute of Heilongjiang Academy of Medical Sciences, Harbin, China
  1. correspondence: Guonian Wang, MD, Department of Anesthesiology, Cancer Hospital of Harbin Medical University, No. 150 Haping Road, Nangang District, Harbin 150081, China (e-mail: wangguonian609cn{at}


Background and Objectives To determine whether stellate ganglion block (SGB) treatment exerts protective effects against isoproterenol (ISO)–induced acute myocardial ischemia (AMI) due to its antioxidant effects, we aimed to evaluate the protective effects of different lateral SGB agents on the tissue antioxidant status in ISO-induced AMI in male Sprague-Dawley rats.

Methods The AMI model received an acute ISO overdose to make cardiac ischemia damage at a single dose of 110 mg/kg injected subcutaneously into the rats. The rats in the SGB groups received SGB 15 minutes after ISO treatment. The data were recorded at the following time points: 0 minutes (T0) and 15 minutes after SGB (T1). The levels of cardiac troponin T and cardiac troponin I and the ST-segment depression in lead III were measured at T0 and T1. The values of oxidative production and antioxidative enzymes in the SG and heart were tested.

Results Stellate ganglion block significantly reduced serum cardiac troponin I and cardiac troponin T levels and mitigated the ST-segment depression and oxidative production levels, but it increased the antioxidative enzymes levels. Right SGB effect was more effective than that of left SGB, in the reduced nitric oxide and malonaldehyde levels, and in the increased superoxide dismutase, glutathione peroxidase, catalase, neuronal nitric oxide synthase, and endothelial nitric oxide synthase levels.

Conclusions These findings suggest that SGB could have antioxidative effects against AMI, and the protective effect of right SGB was more effective than that of left SGB. Thus, the right SGB could be an effective and safe method of local anesthesia to protect against cardiac damage due to oxidative stress.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The authors declare no conflict of interest.

    This research was supported by funds from the Translational Medicine Special Foundation of China Russia Medical Research Center (no. 201519 and CR1418), National Natural Science Foundation of China (NSFC) (81571885), and the Technological and Innovative Talent Foundation of Harbin (2012RFXXS041).

    N.W. helped design the study, analyze the data, and prepare the manuscript. N.W. approved the final manuscript, attests to the integrity of the original data and the analysis reported in this article, and is the archival author. M.C. and L.D. helped with data collection. They also approved the final manuscript. G.W. helped design the study and prepare the manuscript. G.W. approved the final manuscript and attests to the integrity of the original data and the analysis reported in this article.