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Changes in First Postoperative Night Bispectral Index After Daytime Sedation Induced by Dexmedetomidine or Midazolam Under Regional Anesthesia: A Randomized Controlled Trial
  1. Wen-fei Tan, MD, PhD,
  2. Er-ya Miao, MD,
  3. Feng Jin, MD,
  4. Hong Ma, MD, PhD and
  5. Huang-wei Lu, MD, PhD
  1. From the Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, China
  1. Address correspondence to: Wen-fei Tan, MD, PhD, Department of Anesthesiology, the First Hospital of China Medical University, Nanjingbei St 155, Shenyang, China 110001 (e-mail: winfieldtan{at}


Background and Objectives Supplementation of spinal anesthesia with various sedatives is a standard protocol to alleviate patient anxiety associated with the surgical procedure. We hypothesized that, compared with dexmedetomidine, midazolam might have a subtle influence on sleep quality after surgery following elective transurethral prostatic resection (TURP) in elderly male patients.

Methods A randomized, double-blind, controlled trial was conducted at the First Hospital of China Medical University from July 2014 to January 2015. One hundred eleven patients undergoing TURP were enrolled and received intravenous saline infusion (control group), dexmedetomidine (dexmedetomidine group), or midazolam (midazolam group) for sedation during the spinal anesthesia procedure. The intraoperative sedative state and postoperative sleep quality were evaluated using a Bispectral Index (BIS)-Vista monitor. The primary outcome was postoperative sleep quality, as measured by the BIS-Vista monitor on the first night after surgery.

Results The intraoperative BIS area under the curve value was significantly lower in the dexmedetomidine group (54.1%) compared with those in the other 2 groups (control group, 94.1%; midazolam group, 77.2%).The postoperative BIS area under the curve value was highest in the dexmedetomidine group at 88.7%. The BIS sleep efficiency index showed a significant 33.1% increase in the midazolam group compared with the dexmedetomidine group. The duration of sleep in the midazolam group was 237.8 minutes longer than that in the dexmedetomidine group.

Conclusions We conclude that midazolam combined with spinal anesthesia might preserve the sleep quality of elderly male patients immediately after TURP.

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  • The authors declare no conflict of interest.

    This work was funded by the Natural Science Foundation of Liaoning Province (2014021035) through a grant to Wen-fei Tan.

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