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Dose-Finding Methodology for Peripheral Nerve Blocks
  1. Theodosios Saranteas, DDS, MD, PhD,
  2. Roderick J. Finlayson, MD, FRCPC and
  3. De Q. H. Tran, MD, FRCPC
  1. Department of Anesthesia, Montreal General Hospital, McGill University, Montreal, Quebec, Canada
  1. Address correspondence to: De Q. H. Tran, MD, FRCPC, Department of Anesthesia, Montreal General Hospital, 1650 Ave Cedar, D10-144, Montreal, Quebec, Canada H3G 1A4 (e-mail: de_tran{at}


Abstract Dose-finding studies enable the successful conduct of peripheral nerve blocks by ensuring the administration of appropriate doses of local anesthetic. However, the optimal dose-finding methodology remains ambiguous. In this research methodology article, we set out to review the basic aspects pertaining to dose-response curves (graded vs quantal), the pharmacodynamic indices required by dose-finding studies, the properties of different dose-finding methods (sigmoidal dose-response curve analysis, Dixon-Mood method, Biased Coin Design, and Bayesian analysis), as well as strategies and recommendations for future research.

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  • None of the authors received funding for this study.

    The authors declare no conflict of interest.