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Does the Impact of the Type of Anesthesia on Outcomes Differ by Patient Age and Comorbidity Burden?
  1. Stavros G. Memtsoudis, MD, PhD, FCCP*,
  2. Rehana Rasul, MPH, MA,
  3. Suzuko Suzuki, MD*,
  4. Jashvant Poeran, MD, PhD,
  5. Thomas Danninger, MD*,
  6. Christopher Wu, MD,
  7. Madhu Mazumdar, PhD, MA, MS and
  8. Vassilios Vougioukas, MD§
  1. *Department of Anesthesiology, Hospital for Special Surgery
  2. Department of Public Health, Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY
  3. Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD
  4. §Department of Neurosurgery, University of Freiburg, Freiburg, Germany
  1. Address correspondence to: Stavros G. Memtsoudis, MD, PhD, FCCP, Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th St, New York, NY 10021 (e-mail: Memtsoudiss{at}


Introduction Neuraxial anesthesia may provide perioperative outcome benefits versus general anesthesia in orthopedic surgical patients. As subgroup analyses are lacking, we evaluated the influence of the type of anesthesia on outcomes in patient groups of different age and the presence of cardiopulmonary disease.

Methods Data from approximately 500 hospitals in the United States regarding total hip and total knee arthroplasties performed between 2006 and 2012 were accessed. Patients were categorized by age (ie, <65, 65–74, or ≥75 years) as well as the presence of cardiopulmonary disease. Resulting groups were compared with regard to patient, hospital, procedure, and comorbidity-related variables, as well as incidence of major perioperative complications. A multivariable logistic regression analysis was performed to assess the independent influence of the type of anesthesia on complications within each patient subgroup.

Results We identified 795,135 records of patients who underwent total hip arthroplasty or total knee arthroplasty. The incidence of major complications was highest in the oldest patient group with cardiopulmonary disease (26.1%) and the lowest in the youngest group without cardiopulmonary disease (4.5%).

Multivariable logistic regressions showed that neuraxial anesthesia was associated with decreased odds for combined major complications, need for intensive care services, and prolonged length of stay compared with general anesthesia in all patient subgroups. For patients without major cardiopulmonary comorbidities, the positive impact of neuraxial anesthesia increased with increasing age.

Conclusions Neuraxial anesthesia is associated with decreased odds for major complications and resource utilization after joint arthroplasty for all patient groups, irrespective of age and comorbidity burden.

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  • The authors declare no conflict of interest.

    Dr Memtsoudis is supported by the Anna Maria and Stephen Kellen Career Development Award, New York, NY. Contributions of Dr Mazumdar, Dr Poeran, and Mrs Rasul on this project were supported in part by funds from the Clinical Translational Science Center, New York, NY.

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