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Evidence-Based Medicine: Assessment of Ultrasound Imaging for Regional Anesthesia in Infants, Children, and Adolescents
  1. Ban C.H. Tsui, MSc, MD, FRCPC and
  2. Jennifer J. Pillay, BSc
  1. From the Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
  1. Address correspondence to: Ban C.H. Tsui, MSc, MD, FRCPC, Department of Anesthesiology and Pain Medicine, 8-120 Clinical Sciences Bldg, University of Alberta, Edmonton, Alberta, Canada T6G 2G3 (e-mail: btsui{at}


This review was performed to evaluate and discuss the quality and outcomes of studies assessing ultrasound imaging in pediatric regional anesthesia. Literature searches were conducted using MEDLINE and EMBASE, combining the search term "ultrasonography" with "regional anesthesia," "nerve block," "epidural anesthesia," and "spinal anesthesia," with the limit of 0 to 18 years. Additional literature was sought from departmental files and recent issues of several major anesthesiology journals. Meta-analyses/systematic reviews, randomized controlled trials, clinical studies without either randomization or control (eg, comparative studies), and case series (n > 10) were collected, reviewed, and graded for their quality (Jadad scores) and level of evidence (Grades of Recommendation). The search resulted in 211 total publications in pediatric literature, of which 12 were included in the evaluation of peripheral nerve blocks and 12 in the evaluation of neuraxial anesthesia. Although there is some evidence to support ultrasound for various outcomes in pediatric regional anesthesia, more randomized controlled studies with sufficient power are required to further support these findings and to evaluate the potential for ultrasound to reduce complications for regional anesthesia in children.

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  • Dr. Tsui is supported in part by a Clinical Scholar award from the Alberta Heritage Foundation for Medical Research, Edmonton, Alberta, Canada. Jennifer Pillay is supported by institutional/departmental sources.

  • This work is an updated version of that presented at the 34th American Society of Regional Anesthesia and Pain Medicine Annual Meeting, April 2009, Phoenix, AZ.