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Effects of Dexmedetomidine Pretreatment on Bupivacaine Cardiotoxicity in Rats
  1. Volkan Hancı, MD*,
  2. Kemal Karakaya, MD,
  3. Serhan Yurtlu, MD*,
  4. Sedat Hakimoğlu, MD*,
  5. Murat Can, MD,
  6. Hilal Ayoğlu, MD*,
  7. Gülay Erdoğan, MD*,
  8. Rahşan Dilek Okyay, MD* and
  9. Işıl Özkoçak Turan, MD*
  1. From the Departments of *Anesthesiology and Reanimation,
  2. General Surgery, and
  3. Biochemistry, School of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
  1. Address correspondence to: Volkan Hancı, MD, Bahçelievler Mahallesi, Işık Yönder Caddesi, Alay Apt. Kat: 4, Daire: 7, Zonguldak, Turkey (e-mail: vhanci{at}


Background and Objective: We evaluated the effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in anesthetized rats.

Methods: Sixteen Wistar-Albino male rats (300-400 g) were anesthetized with ketamine. Electrocardiographic and invasive blood pressure monitoring were performed, and the results were continuously recorded. The rats were randomized into 2 groups. In group D, rats were pretreated with intravenous dexmedetomidine at a dose of 10 μg/kg (n = 8), whereas in group S, rats were pretreated with intravenous saline (n = 8). Fifteen minutes later, bupivacaine was infused at a rate of 3 mg/kg per minute until cardiac asystole occurred. The timing of specific cardiotoxic events (a 25%, 50%, and 75% reductions of mean arterial pressure and heart rate as well as occurrence of the first arrhythmia and asystole) was recorded.

Results: Dexmedetomidine pretreatment reduced the heart rates and mean arterial pressures of the rats who received it (P < 0.05). Dexmedetomidine pretreatment before bupivacaine administration also significantly increased the time to the 25%, 50%, and 75% reductions in mean arterial pressure and the time to the 25% and 50% reductions in heart rate (P < 0.05). In addition, dexmedetomidine significantly increased the time to first arrhythmia and time to asystole (P < 0.05) in the rats who received it before receiving bupivacaine.

Conclusions: Dexmedetomidine pretreatment delays the effects of bupivacaine cardiotoxicity.

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