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A Randomized, Observer-Blinded Determination of the Median Effective Volume of Local Anesthetic Required to Anesthetize the Sciatic Nerve in the Popliteal Fossa for Stimulating and Nonstimulating Perineural Catheters
  1. Xavier Paqueron, MD, PhD*,
  2. Patrick Narchi, MD*,
  3. Jean-Xavier Mazoit, MD, PhD,
  4. François Singelyn, MD, PhD*,
  5. Alain Bénichou, MD* and
  6. Philippe Macaire, MD*
  1. From the *Department of Anesthesiology and Intensive Care, Centre Clinical, Soyaux; and
  2. University Paris-Sud, Anesthesiology Laboratory, Faculté de Médecine du Kremlin, Le Kremlin-Bicêtre, France.
  1. Address correspondence to: Xavier Paqueron, MD, PhD, Department of Anesthesiology and Intensive Care, Centre Clinical, 2 chemin de Frégeneuil, 16800 Soyaux, France (e-mail: xavier.paqueron{at}


Background and Objectives: Stimulating perineural catheters are developed to overcome technical problems of nonstimulating catheters, but their efficacy remains controversial. However, no volume-response study has compared success rates between stimulating and nonstimulating catheters. This study of stimulating versus nonstimulating catheters compares the minimal effective volume required to successfully block the sciatic nerve in 50% of patients scheduled for unilateral hallux valgus repair.

Methods: Patients underwent unilateral sciatic nerve block in the popliteal fossa with mepivacaine 1.5%, using either a stimulating (STIM group) or a nonstimulating (NONSTIM group) popliteal catheter. The volume of mepivacaine started at 20 mL and was increased or decreased by increments of 2 mL in subsequent patients, depending on the efficacy of the block in the previous patient, using the technique of up-down sequential allocation described by Dixon (Neurosci Biobehav Rev. 1991;15:47-50). Minimum effective volumes of local anesthetic were calculated using the formula of Dixon. Efficacy of block was defined by a complete sensory-motor block in the cutaneous distributions of the sciatic nerve associated with a pain-free surgery.

Results: Twenty-four patients were included in each group. Median effective volume blocking the sciatic nerve was significantly lower (P < 0.05) in the STIM group (2.7 mL; 95% confidence interval, 0.5-4.9 mL) compared with the NONSTIM group (16.6 mL; 95% confidence interval, 15.2-18.0 mL).

Conclusion: Stimulating popliteal catheters dramatically decrease the volume required to block the sciatic nerve in 50% of patients, compared with nonstimulating catheters.

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  • Support was provided solely from departmental sources.

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