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Comparison of 0.25% Levobupivacaine, 0.25% Bupivacaine, and 0.125% Bupivacaine for Duration and Magnitude of Action in Peripheral Arterial Blood Flow Induced by Sympathetic Block in Dogs
  1. Tadaomi Iwasaki, M.D.,
  2. Yoshiyuki Takahashi, M.D., Ph.D.,
  3. Yoshiyuki Kimura, M.D., Ph.D.,
  4. Hajime Yamazaki, M.D., Ph.D.,
  5. Shigeki Yamaguchi, M.D., Ph.D. and
  6. Toshimitsu Kitajima, M.D., Ph.D.
  1. Department of Anesthesiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
  1. Reprint requests: Toshimitsu Kitajima, M.D., Ph.D., Department of Anesthesiology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293 Japan. E-mail: kitajima{at}dokkyomed.ac.jp

Abstract

Background and Objectives: The aim of this study is to compare 0.25% levobupivacaine with 0.25% bupivacaine and 0.125% bupivacaine to examine the duration and magnitude of vasodilative effect induced by sympathetic block.

Methods: We measured mean arterial pressure (MAP), heart rate (HR), and right and left brachial-artery blood flow (BABF) before and after cervicothoracic sympathetic block in 24 dogs. The experimental protocol was designed as follows: (1) left cervicothoracic sympathetic block with 1.0 mL of 0.25% levobupivacaine (n = 8), (2) left cervicothoracic sympathetic block with 1.0 mL of 0.25% bupivacaine (n = 8), and (3) left cervicothoracic sympathetic block with 1.0 mL of 0.125% bupivacaine (n = 8).

Results: MAP and HR did not change significantly throughout the study in either group. Left cervicothoracic sympathetic block with 0.25% levobupivacaine increased left BABF significantly from 5 minutes through 80 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 185 ± 35%; P <.01). Left cervicothoracic sympathetic block with 0.25% bupivacaine increased left BABF significantly from 5 minutes through 100 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 251 ± 47%; P < .01). Left cervicothoracic sympathetic block with 0.125% bupivacaine increased left BABF significantly from 5 minutes through 80 minutes after the block (baseline, 100%; peak at 10 minutes after the block, 155 ± 20%; P < .01).

Conclusions: 0.25% Levobupivacaine may have a lower potency compared with 0.25% bupivacaine in sympathetic block in dogs.

  • Levobupivacaine
  • Bupivacaine
  • Sympathetic block
  • Arterial blood flow

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