Article Text

Download PDFPDF
Lumbar Epidural Analgesia in the Baboon
  1. Laszlo Gyermek, MD
  1. Dr. Gyermek is chief of anesthesiology, Wheeler Hospital, Gilroy, Calif. This study was performed at the University of Stellenbosch Faculty of Medicine, Cape, South Africa, when the author served as visiting senior specialist in anesthesia.


An experimental method for singledose epidural analgesia in the baboon is described. The baboon, when adequately sedated, is a satisfactory species for clinically oriented studies with local analgesic agents. Of the local anesthetics tested, WIN 4510 proved to be the most potent and longest acting. In both respects it significantly surpassed bupivacaine. Attempts to prolong the duration of epidural analgesia by (a) changing the chemical form of the local analgesic (e.g., local analgesic amine base, quaternary ammonium salts), or (b) by using different vehicles (e.g. carboxymethylcellulose, hemacel and dextrane) did not result in significant change in the degree and duration of local analgesic action.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • The author wishes to express his appreciation to Professors P.A. Foster and A. van Zyl and to Mr. T. Zuurmond of the departments of anesthesia and pharmacology, University of Stellenbosch Faculty of Medicine, for their interest, support, and assistance during this study.