Article Text
Abstract
Omission of a confidence interval (CI) associated with the risk of a serious complication can lead to inaccurate interpretation of risk data. The calculation of a CI for a risk or a single proportion typically uses the familiar Gaussian (normal) approximation. However, when the risk is small, “exact” methods or other special techniques should be used to avoid overshooting (risks that include values outside of [0,1]) and zero width interval degeneration. Computer programs and simple equations are available to construct CIs reasonably accurately. In the special case in which the complication has not occurred, the risk estimated with 95% confidence is no worse than 3/n, where n is the number of trials.
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Footnotes
Supported by CUHK Direct Grant 2040785 and departmental funds.
This work is attributable to the Chinese University of Hong Kong, Hong Kong, and the St. Catharines General and Hotel Dieu Hospitals, Canada.