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Effect of Epidural Analgesia on Postoperative Paralytic Ileus in Chronic Schizophrenia
  1. Akira Kudoh, M.D.,
  2. Hiroshi Katagai, M.D. and
  3. Tomoko Takazawa, M.D.
  1. From the Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Japan.
  1. Reprint requests: Akira Kudoh, M.D., Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036-8545, Aomori, Japan.


Background and Objectives Postoperative paralytic ileus is frequently encountered in chronic schizophrenic patients who undergo abdominal surgery. We investigated whether epidural analgesia with local anesthetics minimizes postoperative ileus in schizophrenic patients who are treated long term with antipsychotic drugs.

Methods We measured the VAS pain after surgery and the time that elapsed before the first passage of flatus and/or feces after the end of surgery in schizophrenic patients provided analgesia with systemic buprenorphine (group A) and schizophrenic patients receiving epidural analgesia with local anesthetics (group B).

Results The frequency of patients who did not pass flatus and/or feces for more than 120 hours postoperatively was significantly higher in group A. Postoperative pain scores of group A at 8 and 24 hours after the end of anesthesia were 36.0 ± 12.8 and 31.7 ± 10.7 (0 to 100 mm scale), which were significantly higher than 25.4 ± 13.2 and 20.5 ± 9.4 scores in group B.

Conclusions Epidural analgesia with local anesthetics in chronic schizophrenic patients undergoing abdominal surgery minimizes postoperative ileus compared to patients receiving systemic buprenorphine.

  • Schizophrenia
  • Epidural analgesia
  • Postoperative paralytic ileus

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