The role that uncommon agents of antinociception, placed intrathecally, play in the control of nociceptive signal transmission in the spinal cord is described. Three specific agents are discussed in detail: baclofen, a gamma aminobutyric acid mimetic agent; clonidine, an alpha-2 agonist; and somatostatin, a neuroinhibitory peptide. In addition, the efficacy of using an implanted pump-catheter system for the long-term infusion of baclofen and octreotide, a somatostatin-like analog, is reviewed.
- continuous spinal infusion
- gamma aminobutyric acid
- implantable infusion pumps
- spinal anesthesia.
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Professor and Vice Chairman.
The author thanks Mrs. Lisa Young and Mrs. Kitty Price for their invaluable help in the preparation of this article.