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Case Report
Treatment of Sympathetically Maintained Pain With Terazosin
  1. Donald S. Stevens, M.D.*,
  2. Valerie F. Robins† and
  3. Howard M. Price, M.D.‡
  1. From the Department of Anesthesiology and the Division of Urology, University of Massachusetts Medical Center, Worcester, Massachusetts.
  2. *Assistant Professor/Director, Acute Pain Management Service, Department of Anesthesiology.
  3. †Senior Medical Student.
  4. ‡Assistant Professor, Division of Urology.
  1. Address correspondence and reprint requests to Donald S. Stevens, M.D., Assistant Professor/Director, Acute Pain Management Service, Department of Anesthesiology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.

Abstract

Background and Objectives. α-adrenergic antagonists can be effective in the treatment of sympathetically maintained pain.

Methods. Oral terazosin was prescribed to treat sympathetically maintained pain refractory to other therapies.

Results. The authors describe a patient whose symptoms could not be controlled with commonly prescribed therapies, who obtained total relief of sympathetically maintained pain and vasospasm with terazosin, a new α1 antagonist.

Conclusions. Terazosin is effective in the treatment of sympathetically maintained pain when given once daily because of a long elimination half-time and a long duration of action. This may encourage better patient compliance than do other alpha antagonists of shorter effective duration.

https://doi.org/10.1136/rapm-00115550-199318050-00012

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