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Accidental Overdose of Epidural Bupivacaine and Sufentanil
  1. A. P. Wolff, M.D.*,
  2. M. J. Gielen, M.D., PH.D.,
  3. M. A. Hasenbos, M.D., PH.D.** and
  4. T. H. Liem, M.D.**
  1. From the Institute for Anesthesiology, University of Nijmegen, The Netherlands.
  2. *Resident in Anesthesiology.
  3. Associate Professor in Anesthesiology.
  1. Address reprint requests to A.P. Wolff, M.D., Institute for Anesthesiology, University of Nijmegen, Geert Grooteplein Zuid 10, Postbus 9101, 6500 HB Nijmegen, The Netherlands.


Background and Objectives. A case is described of an accidental high thoracic epidural infusion of 337.5 mg 0.75% bupivacaine and 180 μg sufentanil in less than 30 minutes. It occurred in a post-thoracotomy patient with lung cancer.

Results. Severe hypotension and an extensive sensory and motor block developed. Only a mild respiratory depression was seen. The patient recovered after treatment without adverse sequelae.

  • Bupivacaine
  • sufentanil
  • epidural
  • accidental high infusion rate
  • toxic effects.

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