Article Text

Download PDFPDF

Adding Clonidine to Mepivacaine Prolongs the Duration of Anesthesia and Analgesia after Axillary Brachial Plexus Block
  1. F. J. Singelyn, M.D.,
  2. M. Dangoisse, M.D.,
  3. S. BartholomÉE, M.D. and
  4. J. M. Gouverneur, M.D.
  1. From the Department of Anesthesiology, St. Luc Hospital, UCL School of Medicine, Brussels.
  1. Address correspondence and reprint requests to F.J. Singelyn, M.D., Department of Anesthesiology, St. Luc Hospital, Hippocrate Avenue, 10/1821, B-1200 Brussels, Belgium.


Background and Objectives. This study evaluates the effects of clonidine added to mepivacaine on the duration of anesthesia and analgesia after axillary brachial plexus block.

Methods. Thirty patients scheduled for elective hand surgery were divided into three equal groups in a randomized, double-blinded fashion. An axillary perivascular brachial plexus block was performed with 40 ml 1% mepivacaine plus 1:200,000 epinephrine in the three groups. Group B also received 150 μg clonidine subcutaneously and Group C had the same dose of clonidine mixed with the local anesthetic and injected into the plexus sheath. The following variables were recorded: onset time, duration of anesthesia, duration of analgesia, postoperative pain score, intake of analgesics, and adverse effects.

Results. The three groups were comparable in terms of age, sex, weight, height, onset time of anesthesia, postoperative pain score, and analgesic requirement. The duration of anesthesia and analgesia was comparable in Groups A and B, but both variables were significantly increased in Group C: the duration of anesthesia and analgesia were prolonged, respectively, by 37 ± 6% and 103 ± 16% when compared to Group A and by 32 ± 7% and 89 ± 15% when compared to Group B. No side effects were reported.

Conclusions. One hundred fifty micrograms clonidine added to mepivacaine for brachial plexus block prolongs the duration of anesthesia and analgesia. Our results suggest that this effect of clonidine is local rather than systemic.

  • Regional anesthetic techniques
  • brachial plexus
  • local anesthetics
  • mepivacaine
  • alpha-2 adrenergic agonist
  • clonidine.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Presented in part at the annual meeting of the American Society of Anesthesiology, Las Vegas, October 23, 1990.

    The authors thank P. Baele, M.D., and F. Veyckemans, M.D., for their criticism of the manuscript and their comments.