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Chronic Pain after Methysergide: A New Cause of Ischemic Monomelic Neuropathy
  1. Joseph F. Antognini, M.D.
  1. From the Department of Anesthesiology, University of California—Davis, School of Medicine, Davis


Chronic foot pain developed in a 43-year-old woman after taking methysergide, a potent vasoconstrictor. The etiology was believed to be ischemic monomelic neuropathy, which results from the compromise of blood flow to an extremity. The patient eventually required a surgical sympathectomy after lumbar sympathetic blocks failed to provide permanent relief.

  • Pain
  • neuropathy
  • ergotism
  • sympathectomy

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