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Maternal Analgesia and Neonatal Effects of Epidural Sufentanil for Cesarean Section
  1. Giorgio Capogna, M.D.,
  2. Danilo Celleno, M.D. and
  3. Marco Tomassetti, M.D.
  1. From the Department of Anesthesiology, Ospedale Fatebenefratelli, Isola Tiberina, Rome, Italy.


This study was designed to evaluate the maternal intraoperative and postoperative analgesia and neonatal effects of adding sufentanil to epidural anesthesia for cesarean section before the skin incision. Forty-five multipara were randomized in three equal groups to receive sufentanil 80 μg, 50 μg, or saline with the epidural lidocaine. Intraoperative and postoperative analgesia and side effects were recorded. Infants were evaluated by Apgar score at one and five minutes and by Neurologic and Adaptive Capacity Score and Early Neonatal Neurobehavioral Scale at one, four and 24 hours of life. Superior analgesia, with no intraoperative requirements for supplemental narcotics, was obtained when either 80 μg or 50 μg sufentanil were added to lidocaine. Postoperative analgesia was prolonged after sufentanil, but side effects increased with the greater dose. The infants whose mothers received 80 μg sufentanil showed a mild neurobehavioral depression. It is therefore concluded that the addition of 50 μg of sufentanil improves both intraoperative and postoperative analgesia without significant neonatal effects.

  • Anesthesia: obstetric
  • cesarean section
  • epidural
  • analgesics: sufentanil

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